This idea was conceived over 10yrs ago, it took us 3yrs to control the asymmetry, 3yrs to generate the proof-of-concept demonstrating propulsion and chemotaxis, 2yrs to understand, repeat, create the adequate controls and over 3yrs to get it published. 3 Ph'Ds , 4 PDRAs, and two important collaborations after, we have finally published our demonstration of chemotactic drug delivery. Thanks and congratulations, to Adrian, Claudia, Denis, Sophie, Lorena, Jens, Gavin, Xiaohe, Juzaili, Jane, and Giorgio.
A warm welcome to Dr Edoardo Scarpa who joined us as PDRA in Precision Nanomedicine and will be helping our efforts to characterise and develop new solutions to target brain gliomas. Edoardo, originally from Italy, studied in Lecce for his BSc and in Parma for his MSc. He subsequently moved to Southhampton where he obtained a MRes and Ph'D in Medicine. Edoardo has a lot of experience in developing and characterising polymersomes for biomedical applications and we are very happy to have him in our team.
Elizabeth Ellis, a PhD student with Dr Tung Chun Lee has been working with us on synthesising pH sensitive block copolymers to make different types of nanoparticles. Elizabeth worked with us for over year to learn how to make copolymers with the help of Alessandro. Here she attached pH sensitive copolymers to gold nanoparticles creating a hybrid system that can be used for both carrying drugs as well as for plasmonic and imaging applications.
During inflammation resolution, neutrophils undergo apoptosis before they are removed by macrophages, but if apoptosis is delayed, neutrophils can cause extensive tissue damage and chronic disease. In this work in collaboration with Steve Renshaw from Sheffield and part of James prolific Ph'D, we show we can use PMPC-PDPA polymersomes to deliver cyclin-dependent kinase inhibitor (R)-roscovitine to accelerate inflammation resolution both in vivo and in vitro.
After almost 2yrs of reviewing we have finally published Luca's efforts helped by Loris, Adrian, Lijuan and Andrew Lewis from BTG, on how cancer cells (compared to normal ones) regulate Ki67 proteins. This one of the most common markers for neoplasia. Yet, we know very little about its function and why cancer cells over-express it. We believe this effort will help to shed light on its function and implication in cancer. Well done to Luca, and the rest of the team. Please find the paper in PLoS One.
Our first paper of this year has just been published in Scientific Reports. This reports our efforts in modelling blood brain barrier in vitro where we make brain enthodelial cells polarising tighter by co-culturing them with mesenchymal stem cells conditioned to behave as pericytes. Well done to Joe, now Prof Xiahoe Tian, who led the work.
A bit delayed, but before we disappeared to the winter extravagances, Monika successfully passed her Ph'D viva. She'll be joining us as PDRA for a while looking for new opportunities.
Well done to (Almost)Dr Magon!
A warm welcome to Dr Yiwen Pei who joined us as PDRA in Polymer Chemistry and will be helping our efforts to synthesise new biodegradable copolymers. Yawed, originally from Shanghai, studied in New Zeland for both Bachelor, Master and PhD and after a period in Australia, she moved to the UK. We very happy to have her as part of the team as she brings a unique expertise in polymer chemistry and characterisation.